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血管紧张素Ⅱ使冠(状动)脉和心肌收缩,采用特异性药物阻滞肾素-血管紧张素系统当可扩张冠脉并有负性变力作用。50±10岁的16(男10、女6)例扩张型心肌病患者经冠脉造影未见异常,作为受试者。双侧插管后同时向左、右冠脉主干内注入enalaprilat(MK422,enalapril 的溶液),每侧速率均为0.05mg·min~(-1)(于生理盐水内,1ml·min~(-1)).A 组(12例)开始给药后各项参数改变如下(同给药前相比)。药物的周围循环作用甚弱,唯平均主动脉压降低5%(94±16～90±16mmHg,p<0.06),前负荷指标(如左室舒张末压和左室舒张末容量)和后负荷指标(如左室收缩末应力和体循环血管阻力)
Angiotensin II causes coronary (brachial) artery and myocardial contractions, using specific drugs that block the renin-angiotensin system when it dilates the coronary arteries and has a negative, variable force. There were no abnormal coronary angiography in 16 patients (10 male and 6 female) with dilated cardiomyopathy at 50 ± 10 years old as subjects. After bilateral intubation, enalaprilat (MK422, enalapril solution) was infused into the left and right coronary arteries at a rate of 0.05 mg · min -1 in each side (1 ml · min -1 in saline, 1)). The parameters of group A (n = 12) after the start of administration changed as follows (before administration). Circulation of drugs around the role of very weak, only mean aortic pressure decreased 5% (94 ± 16 ~ 90 ± 16mmHg, p <0.06), preload indicators (such as left ventricular end diastolic pressure and left ventricular end diastolic volume) Indicators (such as left ventricular end systolic stress and systemic vascular resistance)