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[目的]研究微创单侧椎弓根经椎间孔腰椎体间融合术(transforaminal lumbar interbody fusion,TLIF)的临床效果,并比较双侧椎弓根TLIF手术的术后疗效和并发症.[方法]随机选取2005年5月～2008年12月行腰椎后路融合手术40例,单侧手术组(A组)16例,其中男6例,女10例,平均年龄51.75岁.双侧手术组(B组)24例,其中男、女各12例,平均51.92岁.使用Oswestry评分,JOA评分,VAPS视觉类比评分对两组患者术前症状评分及术后疗效参数进行比较,并对两组的手术时间、出血量及融合率进行比较.[结果]单侧组与双侧组随访3～6个月,两组术前与术后3个月的Oswestry评分,JOA评分,VAPS视觉类比评分有统计学差异(P0.05),两组手术时间有统计学差异,A组少于B组,两组出血量无统计学差异,两组术后3个月的融合率为100%,均无术后并发症.[结论]微创单侧椎弓根与双侧椎弓根TLIF手术均有疗效,无统计学差异.“,”[Objective]To compare the postoperatively clinical effects and complications between unilateral and bilateral minimally invasive transforaminal lumbar interbody fusion (TLIF) . [Methods]From May 2005 to December 2008, 40 cases receviving TLIF technique were randomly divided into 2 groups. Unilateral TLIF was applied in 16 cases in group A, with 6 male, 10 female, and average age of 51.75 years. Bilateral TLIF was applied in 24 cases in group B, with 12 male, 12 fe-male, and average age of 51.92 years. Pre-operative conditions and post-operative effects were compared between 2 groups with Oswestry disability index, JOA index, and VAPS index. The operation time, blood loss and healing rates were also com-pared. [Results]All cases were followed up for 3～6 months. In both of the two groups, ODI, JOA, VAPS indexes showed significant differences between pre-and 3 months post-operation (P 0. 05) . Blood loss showed no significant difference (P > 0.05) . Operation time in group A was shorter than that in group B, with significant difference (P 0.05) . No postoperative complication was found in two groups. [Conclusion]Unilateral TLIE technique has achieved satisfying postoperative effect compared with bilateral TLIF, with a good prospect in clinical appli-cation.