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Paul WD 等人对人类的研究已表明,口服2片阿司匹林(血液水平大约2mg/100ml),胃表层上皮细胞损伤超过20%,而且胃粘膜电位差(PD)显著降低。为探讨血高水杨酸盐水平对人胃粘膜的作用,作者给5名正常人静脉输注阿司匹林(3g,2小时输完)和等渗盐水(作对照)各2次,1次在输注时连续测定胃粘膜 PD,另1次在输注前和输注结束时分别作常规胃活检,用光学显微镜和扫描电镜作双重检查。结果输注结束时,血液阿司匹林平均水平为
Studies by Paul WD et al. Have shown that orally administered 2 aspirin (blood level of about 2 mg / 100 ml), gastric epithelial cell damage more than 20%, and gastric mucosal potential difference (PD) was significantly reduced. To investigate the effect of high blood salicylate levels on human gastric mucosa, five normal subjects received intravenous infusion of aspirin (3 g, 2 hours) and isotonic saline (control) Note gastric mucosal PD continuous determination, the other one before and at the end of infusion were routine gastric biopsy, with optical microscopy and scanning electron microscopy for double check. Results At the end of infusion, the average blood aspirin level was