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目的探讨血清CA125、溶血磷脂酸(LPA)联合检测诊断卵巢上皮性癌(EOC)的临床价值。方法选择59例EOC、19例交界性卵巢肿瘤、51例卵巢上皮性良性肿瘤患者及52例健康妇女,采用酶联免疫吸附试验及放射免疫分析法检测其血清CA125及LPA,分析CA125、LPA检测诊断EOC的敏感性和特异性。结果 EOC、卵巢交界性上皮性肿瘤患者的血清CA125、LPA水平明显高于卵巢上皮性良性肿瘤患者及健康妇女(P均<0.05),后两者的CA125、LPA水平比较无统计学差异(P>0.05)。CA125、LPA诊断EOC的敏感性和特异性分别为69.49%、64.71%与83.05%、80.39%,两者联合检测的敏感性和特异性为分别为91.52%、88.23%。结论血清CA125、LPA联合检测可提高诊断EOC的敏感性和特异性,值得临床应用。
Objective To investigate the clinical value of combined detection of serum CA125 and lysophosphatidic acid (LPA) in the diagnosis of epithelial ovarian cancer (EOC). Methods 59 cases of EOC, 19 cases of borderline ovarian tumor, 51 cases of benign ovarian epithelial tumor and 52 healthy women were selected. Serum CA125 and LPA were detected by enzyme linked immunosorbent assay and radioimmunoassay. The levels of CA125 and LPA Diagnosis of EOC sensitivity and specificity. Results The serum levels of CA125 and LPA in patients with EOC and ovarian borderline epithelial tumor were significantly higher than those in patients with benign ovarian epithelial tumors and healthy women (all P <0.05), while the levels of CA125 and LPA in the latter two patients were not significantly different (P > 0.05). The sensitivity and specificity of CA125 and LPA for the diagnosis of EOC were 69.49%, 64.71% and 83.05%, 80.39% respectively. The sensitivity and specificity of the combined detection of CA125 and LPA were 91.52% and 88.23% respectively. Conclusion Serum CA125, LPA combined detection can increase the sensitivity and specificity of diagnosis of EOC, it is worth clinical application.