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目的观察肝素、纳络酮在治疗慢性阻塞性肺疾病(COPD)合并II型呼吸衰竭中的疗效。方法选择临床合乎标准的病例52例,按照平行随机对照方法分为2组,即观察组和对照组,每组26例。观察组用肝素、纳洛酮,肝素钠6250U加入250ml的生理盐水静滴,每日1次,7~15d为1疗程;纳络酮先开始0.4mg静脉推注,然后0.8~1.2mg加入250ml的生理盐水静滴,维持到神志转清,以后每日1次静滴,疗程同前。对照组给予常规呼吸兴奋剂。结果观察组在临床缓解和住院时间上均较对照组明显缩短,差异有显著意义(P<0.05)。结论在治疗COPD并II型呼吸衰竭患者时,使用肝素和纳络酮联合治疗,可取得比较好的疗效。
Objective To observe the curative effect of heparin and naloxone in the treatment of chronic obstructive pulmonary disease (COPD) complicated with type II respiratory failure. Methods Fifty-two clinical cases were selected and divided into two groups according to the parallel randomized controlled trial: observation group and control group, with 26 cases in each group. The observation group with heparin, naloxone, heparin sodium 6250U added 250ml of saline infusion, once daily, 7 ~ 15d for a course of treatment; naloxone 0.4mg intravenous injection, then 0.8 ~ 1.2mg added 250ml Of intravenous saline, to maintain consciousness clear, after intravenous infusion once daily, with the same treatment. The control group was given conventional respiratory stimulants. Results The observation group was significantly shorter than the control group in clinical remission and hospital stay, the difference was significant (P <0.05). Conclusion In the treatment of COPD and type II respiratory failure patients, the use of heparin and naloxone combined treatment, can achieve better results.