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中科院上海巴斯德研究所钟劲研究组通过表达突变型的MAVS蛋白,构建了丙型肝炎(HCV)病毒感染可诱导固有免疫反应的新型细胞系,发现RIG-I并不是HCV病毒感染过程中的关键模式识别受体。相关研究成果已在线发表于《肝脏病学杂志》。HCV是人类的重要病原体,能够通过逃逸宿主的免疫防御系统来建立持续性感染,导致肝硬化和肝癌。病毒在感染过程中被宿主细胞的模式识别受体识别,从而激活固有免疫系统产生抗病毒反应。研究表明RIG-I样受体解旋酶家族中的宿主蛋白RIG-I在肝细胞中转染HCV基因组的3’UTR RNA可以被RIG-I识别并激活干扰素的表达,是HCV的模式识别受体,但该现象从未在HCV病毒感染过程中得到证明。
Zhong Jin, Pasteur Institute, Shanghai Pasteur Institute, Chinese Academy of Sciences, constructed a new cell line capable of inducing an innate immune response to Hepatitis C virus (HCV) infection by expressing a mutant MAVS protein and found that RIG-I was not an HCV infection The key pattern recognition receptors. Relevant research results have been published online in the Journal of Hepatology. HCV is an important human pathogen that can establish a persistent infection by escaping the host’s immune defense system, leading to cirrhosis and liver cancer. The virus is recognized by the host cell’s pattern recognition receptor during infection, thereby activating the innate immune system to produce an antiviral response. Studies have shown that the RIG-I-like receptor helicase family of host protein RIG-I in the liver cells transfected with HCV genome 3 ’UTR RNA can be identified by RIG-I and activate the expression of interferon is HCV pattern recognition Receptor, but this phenomenon has never been demonstrated during the HCV virus infection.