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目的探讨血清同型半胱氨酸(Hcy)与胱抑素C(CysC)在妊高症患者中的临床诊断价值。方法以100例妊高症患者为观察组,根据第6版《妇产科学》中关于妊娠高血压的分类标准将该组再细分为轻度妊高症组32例、中度妊高症组35例和重度妊高症组33例;另选取100例正常健康妊娠产妇为对照组。对上述所有患者的血清Hcy与CysC予以测定,比较观察组与对照组、观察组3个小组之间两项观察指标的水平差异。结果观察组Hcy与CysC水平显著高于对照组,差异有统计学意义(P<0.05);中度妊高症组和重度妊高症组血清Hcy和CysC水平均明显高于轻度妊高症组,差异有统计学意义(P<0.05),重度妊高症组上述两项观察指标水平显著高于中度妊高症组,差异有统计学意义(P<0.05)。结论血清Hcy和CysC水平随着其妊高症严重程度而上升,对于妊高症早期诊断具有指导意义,可作为预测妊高症发生及病情轻重的诊断指标之一。
Objective To investigate the clinical diagnostic value of serum homocysteine (Hcy) and cystatin C (CysC) in patients with pregnancy induced hypertension. Methods According to the classification standard of pregnancy-induced hypertension in the 6th edition of Obstetrics and Gynecology, 100 cases of pregnancy-induced hypertension were selected as the observation group. The patients were further subdivided into 32 cases of mild pregnancy-induced hypertension 35 cases and 33 cases of severe pregnancy-induced hypertension group; the other 100 cases of normal healthy pregnant women as the control group. Serum Hcy and CysC were measured in all the above patients, and the differences between the two groups in the observation group and the control group and the observation group were observed. Results The levels of Hcy and CysC in the observation group were significantly higher than those in the control group (P <0.05). The levels of serum Hcy and CysC in the patients with moderate-severe pregnancy and severe pregnancy-induced hypertension were significantly higher than those with mild pregnancy-induced hypertension Group, the difference was statistically significant (P <0.05), severe pregnancy-induced hypertension group of the above two indicators were significantly higher than those of moderate-high pregnancy group, the difference was statistically significant (P <0.05). Conclusions Serum levels of Hcy and CysC rise with the severity of pregnancy induced hypertension, which may be helpful for the early diagnosis of pregnancy induced hypertension. It may be used as a predictor of pregnancy induced hypertension and severity of illness.