论文部分内容阅读
目的观察自体细胞因子诱导杀伤细胞(CIK细胞)治疗HBVDNA阳性肝硬化患者的近期疗效。方法CIK细胞在体外培养前后以及回输体内后检测CD3+、CD3+CD4+、CD3+CD8+、CD3+、CD5+6、CD2+5细胞以及mDC和pDC。治疗肝硬化患者,比较治疗前后病毒学指标及肝脏功能的变化。结果培养结束以及回输体内后,CD3+细胞、CD3+CD8+细胞、CD3+CD8+细胞较培养前显著升高,mDC和pDC在回输后也明显增高,肝脏功能较治疗前有所好转。所有患者均能耐受治疗。结论CIK细胞可明显提高免疫效应细胞数量,具有一定的抗病毒效应作用,毒副作用低。
Objective To observe the short-term effect of autologous cytokine-induced killer (CIK) cells in the treatment of HBVDNA positive cirrhosis patients. Methods CIK cells were tested for CD3 +, CD3 +, CD4 +, CD3 + CD8 +, CD3 +, CD5 + 6, CD2 + 5 cells and mDC and pDC before and after in vitro culture. The treatment of patients with cirrhosis, compared before and after treatment of virological indicators and liver function changes. Results After the culture was completed and the cells were transfused, the numbers of CD3 + cells, CD3 + CD8 + cells and CD3 + CD8 + cells were significantly higher than those before culture. The mDC and pDC were also significantly increased after transfusion, and the liver function improved compared with that before treatment. All patients can tolerate the treatment. Conclusion CIK cells can significantly increase the number of immune effector cells, have a certain anti-virus effect, low toxicity.