我国是乙肝高发地区且感染途径多样,近年来随着献血管理的加强和乙肝疫苗的逐步推广,HBV感染的水平传播已经逐步得到控制,但仍有10%～20%的婴儿经主、被动联合免疫后阻断失败,研究者指出垂直传播是导致阻断失败的主要原因之一。垂直传播指患者的生殖细胞受病毒感染,在受精时由精子或卵细胞作为载体,将病毒基因带到胚胎进而使子代患病的一种传播方式,可分为母婴传播(M-FT)和父婴传播(P-FT)。本文就P-FT研究进展进行概述并展望其前景。 In our country, the area with high incidence of hepatitis B and various routes of infection, in recent years, with the strengthening of blood donation management and the gradual promotion of hepatitis B vaccine, the level of HBV infection has been gradually controlled, but 10% to 20% of infants still have primary and passive joint After the immune block failure, the researchers pointed out that vertical transmission is one of the main reasons leading to block failure. Vertical transmission refers to the patient’s germ cells infected with the virus, when fertilized by sperm or egg cells as a carrier, the virus gene to the embryo and thus make the offspring of a mode of transmission can be divided into mother-to-child transmission (M-FT) And Parents-to-Infant (P-FT). This article summarizes the P-FT research progress and prospects for its future.