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目的探讨锌及双歧杆菌制剂对早产儿胃动素和胃泌素分泌的影响,为指导早产儿早期喂养提供理论依据。方法对我院NICU的60例早产儿随机分为A、B、C、D4组,A组为对照组,B组加入锌剂、C组加入双歧杆菌制剂、D组同时加入以上两种制剂,出生24h内、生后7d检测血浆胃动素、胃泌素水平。结果4组早产儿生后第1天时,两种激素水平差异无统计学意义(P>0.05),至第7天时,D组早产儿胃动素(365.89±32.60)ng/L胃泌素(138.20±22.11)ng/L与A组胃动素(316.12±38.47)ng/L胃泌素(110.75±27.68)ng/L差异均有统计学意义。治疗组B、C、D3组早产儿血胃动素和胃泌素的变化差值均与对照组A组差异有统计学意义(P<0.05);同时D组与B、C两组差异也有统计学意义(P<0.05)结论早期添加锌及双歧杆菌制剂可以促进早产儿胃动素、胃泌素的释放,加速早产儿胃肠道发育成熟。两种制剂同时添加对早产儿胃肠激素的释放优于单一制剂应用,有利于增进早产儿胃肠功能的发育和完善,加速早产儿的追赶性生长。
Objective To investigate the effects of zinc and bifidobacterium preparations on the secretion of motilin and gastrin in premature infants and to provide a theoretical basis for the early feeding of premature infants. Methods Sixty preterm infants with NICU in our hospital were randomly divided into A, B, C and D4 groups, A group as control group, B group adding zinc agent, C group adding Bifidobacterium preparation, and D group adding the above two preparations , Within 24 hours of birth, 7 days after birth, plasma motilin and gastrin levels were measured. Results There was no significant difference in the levels of two hormones between the first and second prenatal days in the four groups (P> 0.05). On the seventh day, the levels of motilin (365.89 ± 32.60) ng / L, 138.20 ± 22.11) ng / L and group A (316.12 ± 38.47) ng / L gastrin (110.75 ± 27.68) ng / L respectively. The differences of the changes of motilin and gastrin in preterm infants of treatment group B, C and D3 were statistically different from that of control group A (P <0.05); at the same time, the differences of D and B and C Statistical significance (P <0.05) Conclusion The early addition of zinc and bifidobacterium preparations can promote the release of motilin and gastrin in preterm children and accelerate the development of gastrointestinal tract in premature infants. The simultaneous administration of two preparations of gut hormone in premature infants is better than that of single agent in promoting the development and improvement of gastrointestinal function in premature infants and accelerating the catch-up growth of premature infants.