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目的:评价塞来昔布对下颌阻生牙拔除术后急性疼痛的镇痛效果。方法 :90例拔除下颌阻生第三磨牙的患者按随机双盲法分为塞来昔布组、布洛芬组、安慰剂组,每组30例。拔牙4 h后,分别给予塞来昔布400 mg、布洛芬400 mg、维生素C 100 mg。采用视觉模拟评分法(visual analogue scale,VAS),记录患者拔牙4 h后、服药24 h内的疼痛情况及不良反应,利用SPSS 13.0软件包,通过χ2检验和方差分析,比较2种药物的镇痛效果有无显著差异。结果:塞来昔布组、布洛芬组与安慰剂组相比,在镇痛药起效时间、疼痛强度差值(PID)、疼痛缓解程度(PAR)、总疼痛强度差(SPID)、疼痛缓解总和(TOPPAR)、整体评价方面具有显著差异(P<0.05)。塞来昔布组与布洛芬组相比,镇痛效果基本相同,仅服药12 h后两者的PID有显著差异(P<0.05)。服药24 h内,在镇痛起效时间、PAR、SPID、TOPPAR、整体评价方面的差异无显著性(P>0.05)。结论:塞来昔布对下颌阻生牙拔除术后中、重度急性疼痛有明显的镇痛作用。
Objective: To evaluate the analgesic effect of celecoxib on acute pain after mandibular impacted dental extraction. Methods: Ninety patients with mandibular impacted third molar were randomly divided into three groups: celecoxib group, ibuprofen group and placebo group. Each group included 30 patients. Four hours after tooth extraction, celecoxib was given 400 mg, ibuprofen 400 mg, and vitamin C 100 mg respectively. The visual analogue scale (VAS) was used to record the pain and adverse reactions within 24 hours after taking the tooth for 4 hours. SPSS 13.0 software package was used to compare the two kinds of drugs by the χ2 test and analysis of variance No significant difference in pain effect. RESULTS: Compared with placebo group, celecoxib group and ibuprofen group showed significant differences in onset time of analgesia, difference in pain intensity (PID), degree of pain relief (PAR), total pain intensity difference (SPID) Total pain relief (TOPPAR), overall evaluation of significant differences (P <0.05). Compared with the ibuprofen group, the analgesic effect in celecoxib group was basically the same, and the difference was statistically significant (P <0.05) only after 12 h. There was no significant difference (P> 0.05) in the analgesic onset time, PAR, SPID, TOPPAR and overall evaluation within 24 hours after taking the medicine. Conclusion: Celecoxib has obvious analgesic effect on moderate and severe acute pain after mandibular impacted dental extraction.