儿童血清6种元素水平分析和元素间的相互关系

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目的研究6岁以内儿童血清铁(Fe)、镁(Mg)、锌(Zn)、铜(Cu)、钙(Ca)、磷(P)水平及各元素之间的关系,为预防元素失衡引发疾病提供依据。方法选择2014年1月-2015年12月在吉林大学第一医院体检的2 520名儿童为研究对象,其中<1岁组600名,1~3岁组600名,4~6岁组720名,7~12岁组600名。均取静脉血2 ml来检测血清Fe、Mg、Zn、Cu、Ca、P水平。结果 <1岁组血清Fe、Mg、Zn水平低于4~6岁组和7~12岁组(P<0.005);1~3岁组血清Fe、Zn水平低于7~12岁组(P<0.005),血清Cu水平明显高于7~12岁组(P<0.005);4~6岁组血清Fe水平明显低于7~12岁(P<0.005)。血清Fe与Zn水平呈明显正相关(r=0.366,P<0.001),血清Fe与Cu水平呈负相关(r=-0.275,P<0.001),血清Zn与Cu水平呈负相关(r=-0.162,P=0.009),血清Zn与Ca水平呈正相关(r=0.156,P=0.012),与P呈负相关(r=-0.256,P<0.001)。余各元素之间无显著性相关。结论 <1岁婴儿Zn缺乏,Fe、Mg水平也普遍低于年长儿童,需注意补充Zn元素,同时加强膳食中Fe、Mg元素的摄入和平衡;1~3岁幼儿存在Zn缺乏,Fe水平低于年长儿童,故需补充Zn的同时,注意Fe元素的摄入和平衡;4~6岁儿童需注意补充Fe元素。各元素之间存在协调、拮抗等相互作用,因此补充某一元素时需注意剂量适当,同时需注意各元素之间的比例和平衡。 Objective To study the relationship between serum iron (Fe), magnesium (Mg), zinc (Zn), copper (Cu), calcium (Ca) and phosphorus (P) in children under 6 years of age and the various elements in order to prevent the imbalance of elements Disease basis. Methods A total of 2,520 children aged <1 year, 600 children aged 1-3 years and 720 children aged 4 to 6 years were enrolled in this study from January 2014 to December 2015 in the First Hospital of Jilin University. , 7 to 12 years old group 600. Take 2 ml of venous blood to detect serum Fe, Mg, Zn, Cu, Ca, P levels. Results The levels of serum Fe, Mg and Zn in patients <1 year old were lower than those in 4 ~ 6 years old and 7 ~ 12 years old (P <0.005), while the levels of Fe and Zn in children aged 1 ~ 3 were lower than those in 7 ~ 12 years old <0.005). The level of serum Cu was significantly higher than that of patients aged 7-12 years (P <0.005). The level of serum Fe was significantly lower in patients aged 4 ~ 6 years than that of patients aged 7-12 years (P <0.005). There was a significant positive correlation between serum Fe and Zn levels (r = 0.366, P <0.001), serum Fe and Cu levels were negatively correlated (r = -0.275, P <0.001) 0.162, P = 0.009). There was a positive correlation between serum Zn and Ca levels (r = 0.156, P = 0.012) and negative correlation with P (r = -0.256, P <0.001). No significant correlation between the various elements. Conclusions <1-year-old infants lack Zn, Fe and Mg levels are generally lower than those of older children, and zinc supplementation should be paid attention to, while the intake and balance of dietary Fe and Mg should be enhanced. Zn deficiency and Fe Level below the older children, so need to add Zn at the same time, pay attention to the intake of Fe and balance; 4 to 6-year-old children need to pay attention to add Fe element. Coordination between the elements, antagonism and other interactions, so add a certain element should pay attention to the appropriate dose, taking into account the ratio between the elements and the balance.
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