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目的对儿童再生障碍性贫血淋巴细胞亚群及其与血常规的相关性进行研究。方法再生障碍性贫血患儿30例作为观察组。选择同期于本院接受健康体检,且已证实不存在再生障碍性贫血的患儿30例作为对照组。将外周血淋巴细胞亚群指标与健康对照组患儿进行对比,同时分析与同期血常规的相关性。结果观察组CD3+CD4+;CD3+CD4+/CD3+CD8+;CD19+均明显低于对照组,CD3+CD8+明显高于对照组,差异有统计学意义(P<0.05)。观察组CD3+CD8+检出值与HB、WBC呈正相关关系,CD3+CD4+/CD3+CD8+检出值与HB、WBC、N呈负相关关系(P<0.05)。结论儿童再生障碍性贫血疾病会导致淋巴细胞亚群的失调反应。T淋巴细胞介导下免疫异常对造血功能有明显抑制。
Objective To study the correlation between lymphocyte subsets of children with aplastic anemia and their blood routine. Methods 30 cases of children with aplastic anemia as observation group. Select the same period in our hospital for medical examination, and confirmed the absence of aplastic anemia in 30 children as a control group. Peripheral blood lymphocyte subsets were compared with healthy control children, and the correlation with blood routine was analyzed. Results The levels of CD3 + CD4 +, CD3 + CD4 + / CD3 + CD8 + and CD19 + in the observation group were significantly lower than those in the control group, and the levels of CD3 + CD8 + in the observation group were significantly higher than those in the control group (P <0.05). The detection value of CD3 + CD8 + in observation group was positively correlated with HB and WBC. The detection value of CD3 + CD4 + / CD3 + CD8 + was negatively correlated with HB, WBC and N (P <0.05). Conclusion Childhood aplastic anemia can lead to dysregulation of lymphocyte subsets. T lymphocyte-mediated immune abnormalities significantly inhibited hematopoietic function.