论文部分内容阅读
为探讨缺氧缺血性脑病发病机制与血液流变学的关系，对１９例新生儿缺氧缺血性脑病（ＮＨＩＥ）和１６例正常新生儿进行血液流变学综合指标对照观察。结果显示：患病组的血浆比粘度（ηｐ）、红细胞变形指数（ＴＫ）、红细胞聚集指数（ＲＡＩ）、微循环滞留时间（ＭＳＴ）、纤维蛋白原（Ｆｉｂ）、血栓形成系数（ＴＦＬ）均高于对照组，差异有非常显著性意义（Ｐ＜０．０１）。血液粘度（ηｂ）及还原粘度（ηｒ）也比正常组高（Ｐ＜０．０５）。红细胞压积（Ｈｃｔ）两组对照无显著性差异（Ｐ＞０．０５）。表明新生儿缺氧缺血性脑病存在着血液高粘滞，其主要原因为红细胞的聚集性增高和变形能力下降，以及血浆纤维蛋白原增加。
To investigate the relationship between the pathogenesis of hypoxic-ischemic encephalopathy and hemorheology, 19 hemodialysis patients with neonatal hypoxic-ischemic encephalopathy (NHIE) and 16 normal neonates were enrolled in this study. The results showed that the plasma specific viscosity (ηp), erythrocyte deformability index (TK), erythrocyte aggregation index (RAI), microcirculation retention time (MST), fibrinogen and thrombus formation factor Higher than the control group, the difference was significant (P <0.01). Blood viscosity (ηb) and reducing viscosity (ηr) also higher than the normal group (P <0.05). There was no significant difference between two groups in hematocrit (Hct) (P> 0.05). That neonatal hypoxic-ischemic encephalopathy there is a high blood viscosity, mainly due to increased aggregation of red blood cells and decreased ability to deform, and increased plasma fibrinogen.