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分别采用直线加速器β射线和~(60)Co源γ射线外照射动物局部组织,试建立放射性皮肤烧伤动物模型;观察了局部组织代谢指标的改变及组织病理变化,以选择放射性皮肤烧伤的较佳动物模型及揭示放射性皮肤损伤产生的分子机制。实验结果显示:(1)γ射线外照射可引起局部组织代谢指标的改变,在大剂量组可引起深部溃疡,而同时伴有的全身性损伤易引起动物死亡;(2)β射线外照射在15Gy及以下剂量组可引起局部代谢指标改变,但不引起致死性损伤,而45Gy组能产生深Ⅱ度创面溃疡,且与γ射线外照射比较,死亡率大大降低;(3)不论γ或β射线都能引起局部皮肤损伤改变,并在生化代谢指标方面有诸多相似之处。由此可知:以直线加速器制造的放射性皮肤烧伤动物模型具有可靠性和易行性,值得推广采用。
Radiological skin burns animal models were established by using linear accelerator β-ray and ~ (60) Co γ-ray external irradiation. The changes of local tissue metabolic indexes and histopathological changes were observed to select the better radioactive skin burns Animal model and reveal the molecular mechanism of radiation skin damage. The experimental results show that: (1) γ ray irradiation can cause local tissue metabolic changes in the high-dose group can cause deep ulcers, while accompanied by systemic injury can cause animal death; (2) β-ray external irradiation in 15Gy and below dose group can cause local metabolic changes, but does not cause fatal injury, and 45Gy group can produce deep second-degree wound ulcers, and compared with γ-ray irradiation, the mortality rate was significantly reduced; (3) regardless of γ or β Ray can cause local skin lesions change, and biochemical metabolic indicators have many similarities. It can be seen that: the animal model of radiofrequency skin burns manufactured by linear accelerator has the reliability and feasibility, which is worth popularizing and adopting.