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目的:研究回肠Na+/胆酸转运体(IBAT)抑制剂SC-435喂养后,豚鼠胃肠移行性复合波(MMC)与胆酸池大小的变化。方法:60只豚鼠分别给予正常饮食和IBAT抑制剂SC-435饮食2周、4周、8周。喂养结束后,评估胆囊动力并将4对电极植入胃窦、12指肠、空肠、回肠。7d后,记录MMC并测量胆酸池大小。结果:IBAT抑制剂喂养后,胆囊动力在4周与8周组下降。胆酸池在4周组减小17.11%(P<0.05),8周组减小48.35%(P<0.05)。MMC起源部位发生改变:胃窦起源(37%)和十二指肠起源(46%)减少而空肠起源(17%)增多。与对照组相比,MMC周期延长(4周组1.16倍,P<0.05;8周组1.38倍,P<0.05)而波幅降低(4周组降低10.58%,P<0.05;8周组降低49.17%,P<0.05)。在对照组与2周组之间,所有MMC参数无统计学意义差异。结论:IBAT抑制剂SC-435减小胆酸池并抑制MMC运动;MMC与胆酸肠肝循环有关,与胆酸池大小改变一致。
Objective: To study the changes of gastrointestinal metaplastic composite wave (MMC) and bile acid pool in guinea pigs fed with ileal Na + / bile acid transporter (IBAT) inhibitor SC-435. Methods: Sixty guinea pigs were given normal diet and IBAT inhibitor SC-435 diet for 2 weeks, 4 weeks and 8 weeks respectively. After feeding, gallbladder motility was assessed and 4 pairs of electrodes were implanted in the antrum, 12 of the jejunum, jejunum, and ileum. After 7 days, record the MMC and measure the cholic acid pool size. RESULTS: After IBAT inhibitor feeding, gallbladder motility decreased at 4 and 8 weeks. The bile acid pool decreased by 17.11% (P <0.05) in 4 weeks and 48.35% (8 weeks) in 8 weeks (P <0.05). The origin of MMC changes: the origin of the antrum (37%) and the origin of the duodenum (46%) decrease while the origin of the jejunum (17%) increases. Compared with the control group, the MMC cycle was prolonged (1.16-fold in 4-week group, P <0.05; 1.38-fold in 8-week group, P < %, P <0.05). There was no statistically significant difference in all MMC parameters between the control group and the 2-week group. Conclusions: The IBAT inhibitor SC-435 can reduce the cholic acid pool and inhibit the movement of MMC. MMC is related to the enterohepatic circulation of cholestasis and is consistent with the change of bile acid pool size.