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阿霉素具有逆行性轴浆运输的特点,其对周围感觉神经节的毒性作用具有高度选择性。近年来,阿霉素的逆行性感觉神经节切除术已被应用于临床治疗一些顽固性神经痛。本文将重点介绍阿霉素对感觉神经节细胞的毒性机制、特点及其临床应用。
Adriamycin has the characteristics of retrograde axonal transport, which is highly selective for the toxic effects of peripheral sensory ganglia. In recent years, doxorubicin retrograde sensory ganglionectomy has been used in the clinical treatment of some intractable neuralgia. This article will focus on the doxorubicin sensory ganglion cell toxicity mechanism, characteristics and clinical application.