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大鼠于妊娠第9天按10mg/10mg一次肌肉注射国产米非司酮,分别在给药后8h及24h处死,观察胚胎发育及蜕膜组织学、组织化学及超微结构改变。实验结果表明,给药后8h蜕膜细胞变性,ACP活性增强,糖原含量减少,AKP、SDH活性变化不明显。电镜下观察蜕膜细胞核型不规则,核染色质边集并集聚成块,线粒体肿胀,内质网扩张,糖原区消失等变化。24h后蜕膜细胞全部变性坏死,ACP活性增高,AKP、SDH亦明显减弱,糖原消失。文中讨论了蜕膜组织变性坏死与药物终止早孕机理的关系。本实验未观察到药物对卵巢黄体3β-HSD的抑制作用。
The rats were intramuscularly injected with domestic mifepristone at the dose of 10mg / 10mg on the 9th day of gestation. The rats were sacrificed at 8h and 24h respectively. The development, decidual histology, histochemistry and ultrastructure of the rats were observed. The experimental results showed that the degeneration of decidual cells 8 h after administration, ACP activity increased, glycogen content decreased, AKP, SDH activity did not change significantly. Under electron microscope, the morphological changes of the decidua cells were observed, such as irregular karyotype, clustering of nuclear chromatin and aggregation, swelling of mitochondria, dilation of endoplasmic reticulum and disappearance of glycogen. All decidual cells degeneration and necrosis 24 hours later, ACP activity increased, AKP, SDH also significantly decreased, glycogen disappeared. The article discusses the relationship between decidual degeneration and necrosis and drug termination of early pregnancy mechanism. This experiment did not observe the drug on ovarian luteal 3β-HSD inhibition.