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本研究的目的是优化二甲基姜黄素类脂囊泡的制备工艺,提高二甲基姜黄素溶解度,并考察二甲基姜黄素类脂囊泡的稳定性.通过薄膜分散法制备负载二甲基姜黄素类脂囊泡,采用单因素考察法优化处方组成和制备工艺,探究其溶解性并进行质量评价.工艺优化后制备的二甲基姜黄色素类脂囊泡的平均粒径为(310.3±0.9) nm,包封率为(88.1±1.7)％,载药量为(4.03±1.05)％,渗漏率在45天内低于2％.这些发现均表明类脂囊泡作为二甲基姜黄素的载体显著提高其溶解度,并有很好的稳定性,使得二甲基姜黄素作为抗癌药物在药物应用中具有很好的应用前景.“,”In the present work,we aimed to optimize the preparation technology of dimethyl curcumin niosomes,improve its solubility and assess its stability.The novel anti-androgen dimethyl curcumin niosomes were prepared by thin-film dispersion-ultrasonic method,and the prescription composition and preparation process were optimized by single-factor investigation method.Certainly,the solubility and quality evaluation of dimethyl curcumin niosomes were also investigated.The average particle size of prepared dimethyl curcumin niosomes was (310.34±0.9) nm.The highest encapsulation rate was 88.1 ％± 1.7％,and the drug-loading amount was 4.03％±1.05％.Moreover,the leakage rate was below 2％ within 45 d.Collectively,all these findings indicated that the niosomes,as a vector,could significantly improve the solubility and stability of dimethyl curcumin,offering a theoretical basis for dimethyl curcumin as an anticancer drug in medicine application.