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目的:研究脑外伤后血清、脑脊液中髓鞘碱性蛋白(myelin basic protein,MBP)浓度变化,探讨该变化与脑损伤程度及预后情况的关系。方法:采用酶联免疫吸附法对65例脑外伤患者伤后24h、3d、7d血清及脑脊液中MBP浓度检测,并结合颅脑损伤程度和格拉斯哥预后计分(GOS)进行比较分析。结果:病例组患者血清和脑脊液中MBP含量升高程度与脑损伤程度及预后情况密切相关。结论:血清、脑脊液MBP对于判断脑外伤程度和预后情况具有较高的特异性和敏感性,可作为脑外伤治疗及病情转归的重要客观依据。
Objective: To study the changes of the concentration of myelin basic protein (MBP) in serum and cerebrospinal fluid (CSF) after traumatic brain injury and to explore the relationship between the changes and the degree of brain injury and prognosis. Methods: MBP concentrations in serum and cerebrospinal fluid (CSF) of 65 traumatic brain injury patients were detected by enzyme-linked immunosorbent assay (ELISA) at 24h, 3d and 7d after injury, and compared with craniocerebral injury and Glasgow prognostic score (GOS). Results: The elevated level of MBP in serum and cerebrospinal fluid of patients in the case group was closely related to the degree of brain injury and prognosis. Conclusion: Serum and cerebrospinal fluid MBP is highly specific and sensitive in judging the degree and prognosis of traumatic brain injury. It may serve as an important objective basis for the treatment of traumatic brain injury and the prognosis of the disease.