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目的探讨胃癌患者血清中血管内皮生长因子(VEGF)的表达及其与临床病理分期和预后的相关性。方法应用酶联免疫吸附法(ELISA)检测165例胃癌患者和45例健康志愿者血清中VEGF表达水平,并分析VEGF水平与与临床病理分期和预后的关系。结果胃癌患者血清中VEGF表达水平明显高于健康志愿者(P<0.05),其中Ⅲ~Ⅳ期胃癌患者血清中VEGF水平明显高于Ⅰ~Ⅱ期胃癌患者(P<0.05),出现转移者VEGF水平明显高于未发生转移者。结论 VEGF水平不仅与胃癌临床分期相关,而且也与预后密切相关,检测血清中VEGF的表达水平具有重要的临床意义。
Objective To investigate the expression of vascular endothelial growth factor (VEGF) in patients with gastric cancer and its relationship with clinicopathologic stage and prognosis. Methods Serum levels of VEGF in 165 gastric cancer patients and 45 healthy volunteers were detected by enzyme-linked immunosorbent assay (ELISA), and the relationship between VEGF and clinical stage and prognosis was analyzed. Results The serum levels of VEGF in gastric cancer patients were significantly higher than those in healthy volunteers (P <0.05). The serum levels of VEGF in patients with stage Ⅲ ~ Ⅳ gastric cancer were significantly higher than those in patients with stage Ⅰ ~ Ⅱ gastric cancer (P <0.05) The level was significantly higher than those who did not shift. Conclusion The level of VEGF is not only correlated with the clinical stage of gastric cancer, but also with the prognosis. Detecting the expression of VEGF in serum has important clinical significance.