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目的 :观察复方甘草酸苷注射液治疗妊娠合并慢性乙型肝炎 (乙肝 )患者的疗效。方法 :妊娠合并慢性乙肝患者共 63例 ,分为治疗组 3 3例 ,对照组 3 0例。治疗组用复方甘草酸苷注射液 80mL加入 5 %葡萄糖注射液 2 5 0mL中静脉滴注 ,qd ,4周为 1个疗程 ;对照组 :用甘草酸二铵注射液 15 0mL加入 5 %葡萄糖注射液 2 5 0mL中静脉滴注 ,qd ,4周为 1个疗程。观察患者治疗前后的临床症状及体征、胎心音、胎动情况 ;检查治疗前后肝功能、电解质、血常规、尿常规 ,血清病原学指标等。结果 :治疗组有效率 87.9% ,对照组有效率 83 .3 % ( χ2 检验 ,P >0 .0 5 )。两组均未发现不良反应。结论 :复方甘草酸苷注射液可改善妊娠合并慢性乙肝患者的肝功能 ,与甘草酸二铵注射液疗效相似。
Objective: To observe the curative effect of compound glycyrrhizin injection on pregnant women with chronic hepatitis B (hepatitis B). Methods: A total of 63 pregnant women with chronic hepatitis B were divided into treatment group (33 cases) and control group (30 cases). The treatment group with compound glycyrrhizin injection 80mL added 5% glucose injection 25OmL intravenous infusion, qd, 4 weeks for a course of treatment; control group: diammonium glycyrrhizinate injection 15OmL 5% glucose injection Liquid 250mL intravenous infusion, qd, 4 weeks for a course of treatment. Observed before and after treatment of patients with clinical symptoms and signs, fetal heart sound, fetal movement; check before and after treatment of liver function, electrolytes, blood, urine, serum etiology and other indicators. Results: The effective rate was 87.9% in the treatment group and 83.3% in the control group (χ2 test, P> 0.05). No adverse reactions were found in both groups. Conclusion: Compound glycyrrhizin injection can improve liver function in patients with chronic hepatitis B during pregnancy, which is similar to that of diammonium glycyrrhizinate injection.