本文主要介绍近年对哮喘发病机理的新认识。包括对血清 IgE 异常增高的调节控制机理的探讨,有认为 T 细胞亚群参与了 IgE 的合成调节,此外一些体液因子也起重要作用。同时并对哮喘气道炎症的形态学依据,气道炎症细胞、炎症介质以及气道高反应性在其发病中的重要作用进行了阐述,为进一步寻求防治哮喘新药提供理论基础。 This article introduces the new understanding of the pathogenesis of asthma in recent years. Including the discussion of the regulatory mechanism of abnormal increase in serum IgE, it is thought that the T cell subsets participate in the synthesis regulation of IgE, and besides, some humoral factors play an important role. Meanwhile, the morphological basis of airway inflammation in asthma, the important role of airway inflammatory cells, inflammatory mediators and airway hyperresponsiveness in the pathogenesis of asthma were elaborated, providing a theoretical basis for further seeking new drugs for preventing and treating asthma.