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本文主要综述G蛋白各α亚基、βγ二聚体、G蛋白偶联受体(G protein-coupled receptors,GPCRs)和丝裂原激活的蛋白激酶(mitogen-activated protein kinases,MAPK)在细胞增殖和肿瘤发生过程中的作用;以及从GPCRs到MAPK的信号传导途径和该途径中的一些癌基因产物;最后说明从GPCRs至JNK(c-jun kinase)的一种新的细胞增殖信号传导途径。
This review mainly focuses on the role of G protein-α subunits, βγ dimers, G protein-coupled receptors (GPCRs) and mitogen-activated protein kinases (MAPK) And tumorigenesis; as well as signaling pathways from GPCRs to MAPKs and some oncogenes in this pathway; and finally a new cell proliferation signaling pathway from GPCRs to JNK (c-jun kinase).