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目的：了解女性非淋菌性阴道炎患者生殖道支原体感染状况及支原体抗菌药物的敏感性，指导临床合理用药。方法选取我院2014年1~12月妇科送检的3902例生殖道分泌物标本，采用珠海迪尔生物工程有限公司生产的支原体分离培养药敏试剂盒进行型别鉴定及药敏试验。结果支原体总阳性感染率为55.1％，解脲脲原体（Uu）、人型支原体（Mh）及Uu＋Mh混合感染的阳性率分别为67.4％、4.7％、27.9％。药敏结果显示，支原体对交沙霉素、美满霉素、强力霉素的敏感性较高，其敏感率分别为100％、91.6％、91.2％，对环丙沙星耐药率最高（82.8％）；阿奇霉素、罗红霉素、克拉霉素等大环内酯类常用药物，虽对单纯Uu感染的敏感性高，但是对有Mh感染时抗菌活性差，应用时应慎重考虑。结论交沙霉素、美满霉素、强力霉素可作为治疗支原体感染的经验用药，对于不同类型的支原体的感染，临床医师应根据药物敏感试验报告合理选择抗菌药物。“,”Objective To understand the genital tract Mycoplasma infection status and sensitivity of Mycoplasma an-tibacterial drugs of female patients with non-gonoccus vaginitis to guide clinical rational drug use. Methods 3902 geni-tal tract secretions samples inspected by department of gynecology from January 2014 to December 2014 were selected. Mycoplasma isolation culture drug sensitivity kit produced by Zhuhai Deere biological engineering co., Ltd., was used to conduct type identification and drug sensitive test. Results The total positive infection rate of Mycoplasma was 55.1% and positive rate of Uu,Mh and mixed infection of Uu+Mh was 67.4 %,4.7% and 27.9% respectively.The drug sensitivity results showed that josamycin,minocycline and doxycycline had higher sensibility to Mycoplasma and the sensitive rate was100%,91.6% and 91.2% respectively.Ciprofloxacin had the highest drug resistance rate (82.8%) in Mycoplasma.Large ring lactone class commonly used drugs liked azithromycin,roxithromycin and clarithromycin,through had higher sensitive to simple Uu infection,they had poor antibacterial activity to Mh infection.So it should be consid-ered when applied. Conclusion Josamycin,minocycline and doxycycline can be the empirical antibiotics for Mycoplas-ma infection.For different types of Mycoplasma infection,the doctors should be chose antimicrobial reasonable according to drug sensitive test report.