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DBC1最早发现是在乳腺癌中杂合性缺失,被称为乳腺癌缺失基因1(deleted in breast cancer 1).DBC1在基因表达、细胞周期及凋亡、肿瘤发生等过程中均有不同的调节作用.随着研究的不断深入,对DBC1的表达进行调控很可能成为肿瘤,炎症以及代谢性疾病重要的干预靶点.本文对DBC1在肿瘤、淋巴细胞功能和部分代谢性疾病中的作用进行综述.“,”Deleted in breast cancer 1 (DBC1) gene was first found to be heterozygous for deletion in breast cancer.Recent studies have demonstrated that DBC1 plays different roles in gene expression,cell cycle,apoptosis and tumor occurrence.Therefore,it may be a therapeutic target for cancer,inflammation and metabolic diseases.This review summarized the roles of DBC1 in tumor progression,lymphocytes function and some metabolic diseases.