80多年前Feber报告了一例多发性肠狭窄合并恶性贫血者,称其为盲袢综合征(小肠污染综合征)。Cameron等(1949)在大鼠建立了空肠盲袢,表明由于维生素B_(12)吸收不良,很快产生贫血和体重减轻。盲袢本身损伤很小,但其中含有大量细菌,以厌氧菌占优势,这种上段小肠细菌过度生长,尤其某些厌氧分解胆盐 More than 80 years ago, Feber reported a case of multiple intestinal stenosis with pernicious anemia, called blind syndrome (small intestine pollution syndrome). Cameron et al. (1949) established a jejunum blind in rats, indicating rapid anemia and weight loss due to malabsorption of vitamin B_ (12). Blind itself is very small damage, but which contains a large number of bacteria to anaerobic dominant, this upper intestinal bacteria over-growth, in particular, some anaerobic decomposition of bile salts