器官移植成败的关键在于对排异反应的抑制。自从普遍使用环孢素(CycloporinA)以来,提高了器官移植的成功率,欧美一些国家广泛地施行了这种手术。环孢素的确是比以前使用的硫噻嘌呤优越得多的免疫抑制剂,然而正当人们都认为它无疑是最好的免疫抑制剂的时候,作者有幸在藤泽制药公司发现了新的免疫抑制剂 TK506不久就得到了对此化合物进行研究的机会。通过体外实验的研究结果可以预测,在体内器官移植实验中会取得良好的效果。目前(1990年8月)美 The key to the success or failure of organ transplantation is rejection of rejection. Since the widespread use of cyclosporin A (Cycloporin A) has been to improve the success rate of organ transplantation, a number of countries in Europe and the United States conducted such a wide range of operations. Cyclosporine is indeed a much superior immunosuppressant than previously used thiopurine, but while it is widely accepted as the best immunosuppressant, the authors were fortunate to have found a new immunosuppression at Fujisawa Pharmaceuticals Agent TK506 soon got the opportunity to study this compound. The result of in vitro experiments predicts good results in vivo organ transplantation experiments. Present (August 1990) United States