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[目的]比较托烷司琼(单药组)、托烷司琼+地塞米松(双药组)、托烷司琼+地塞米松+甲地孕酮(佳迪)(三药组)三种不同止吐治疗在预防顺铂所致的消化道不良反应的疗效差别。[方法]接受含顺铂方案化疗的98例肺癌患者,分别接受以上三种不同预防止吐治疗,观察化疗后的恶心呕吐、食欲下降、体重下降和ECOG变化情况。[结果]在恶心、呕吐方面,三药组最轻,单药组最重。在改善厌食程度、提高体能状态评分上三药联合组有一定的优势。[结论]佳迪能增强常规止吐治疗在顺铂所致的消化道反应中的疗效。
[Objective] To compare tropexetron (single drug group), tropisetron + dexamethasone (double drug group), tropisetron + dexamethasone + megestrol (Jiadi) (three drugs group) The effect of three different antiemetic treatments on the prevention of cisplatin-induced gastrointestinal adverse effects. [Methods] Ninety-eight patients with lung cancer who received chemotherapy with cisplatin regimen received each of three different anti-prevention treatments. The incidence of nausea and vomiting, loss of appetite, weight loss, and ECOG after chemotherapy were observed. [Results] In terms of nausea and vomiting, the three drugs group was the lightest and the single drug group was the heaviest. The three-drug combination group has certain advantages in improving the degree of anorexia and improving the physical fitness score. [Conclusion] Jiadi can enhance the efficacy of conventional antiemetic therapy in cisplatin-induced gastrointestinal reactions.