硝苯吡啶与尼卡地平和异搏停等钙离子拮抗剂正式作为高血压阶梯治疗第3阶梯用药已广泛地应用于临床,并渐成为降压首选药,今就硝苯吡啶治疗高血压有关问题讨论如下:一、降压机制:近年来有关高血压“细胞膜离子转运缺陷”的研究重点已转移到“钙代谢与高血压的关系”上来,外周血管阻力增高与钙有关,钙进入平滑肌细胞后被调钙蛋白结合,一 Nifedipine and nicardipine and verapamil and other calcium antagonists officially used as the third step of hypertensive ladder treatment has been widely used in clinical and gradually became the preferred antihypertensive drugs, nifedipine treatment of hypertension-related The issues discussed are as follows: First, the antihypertensive mechanism: In recent years, the focus of research on hypertension “cell membrane ion transport defects” has shifted to “the relationship between calcium metabolism and hypertension,” increased peripheral vascular resistance and calcium, calcium into smooth muscle cells After calmodulin binding, one