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目的:探索细针抽吸活组织检查(FNAB)和PCR-SSP协同检测对胰腺良恶性肿块鉴别及对胰腺癌的诊断价值.方法:对35例胰腺癌、12例正常胰腺组织、26例胰腺良性疾病、8例壶腹癌及7例胆管癌行FNAB,并对FNAB吸出物行PCR-SSP检测K-ras基因有无突变.结果:FNAB对胰腺癌的确诊率为57.1%(20/35),对壶腹癌及胆管癌的确诊率分别为4/8(50)和4/7(5.1%);PCR-SSP对胰腺癌的确诊率为91.4%(32/35),对壶腹癌及胆管癌的确诊率皆为零.结论:FNAB与PCR-SSP协同检测有助于确诊胰腺癌;PCR-SSP对壶腹癌及胆管癌的诊断价值不大.
Objective: To explore the value of FNAB and PCR-SSP in the differential diagnosis of benign and malignant pancreatic tumors and their diagnostic value for pancreatic cancer. Methods: 35 cases of pancreatic cancer, 12 cases of normal pancreas, and 26 cases of pancreas Benign disease, 8 cases of ampullary carcinoma and 7 cases of cholangiocarcinoma were performed with FNAB. PCR-SSP was used to detect K-ras gene mutations in FNAB aspirate. Results: The diagnosis rate of FNAB in pancreatic cancer was 57.1% (20/35). The definitive diagnosis rates for ampullary carcinoma and cholangiocarcinoma were 4/8 (50) and 4/7 (5.1%), respectively; the confirmed rate of PCR-SSP for pancreatic cancer was 91.4% (32/35). The diagnosis rate of cancer and cholangiocarcinoma were both zero. Conclusion: The combined detection of FNAB and PCR-SSP is helpful for the diagnosis of pancreatic cancer; PCR-SSP has little value in the diagnosis of ampullary carcinoma and cholangiocarcinoma.