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炎症性肠病(IBD)包括克罗恩病(CD)和溃疡性结肠炎(UC),近年来发病呈上升趋势。IBD的发病机制尚不明确,越来越多的证据表明遗传易感性在IBD的发病中起重要作用,本文概述近年关于IBD遗传易感性的研究进展,主要讨论近年报道较多的被认为与IBD有关的几个易感基因。
Inflammatory bowel disease (IBD) includes Crohn’s disease (CD) and ulcerative colitis (UC), with an increasing incidence in recent years. The pathogenesis of IBD is not clear. More and more evidences indicate that genetic susceptibility plays an important role in the pathogenesis of IBD. This review summarizes recent advances in genetic susceptibility to IBD. The main topics discussed in recent years are reported to be associated with IBD Several related genes are susceptible.