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临床上,抗生素的联合使用是非常普遍的,如何正确使用发挥最大治疗效果,减少毒副作用是我们医药工作者十分关心的问题,本文就抗生素的联合使用原则进行讨论。一、抗生素分类:本文根据抗生素对微生物的作用方式分为:(一)繁殖期杀菌剂:包括青霉素类,头孢菌素类、万古霉素、磷霉素等。此类药物主要通过抑制糖肽基本单位交叉连结成大分子粘肽,导致细菌的细胞壁合成障碍,造成细菌细胞壁缺损而起杀菌作用。
Clinically, the combined use of antibiotics is very common, how to use the maximum effect of the correct treatment to reduce side effects is our medical workers are very concerned about the issue of antibiotic joint use of this article to discuss. First, the antibiotic classification: This article is based on the role of antibiotics on microbes are divided into: (a) breeding season fungicides: including penicillins, cephalosporins, vancomycin, fosfomycin and so on. Such drugs mainly by inhibiting the glycan peptide cross-linked into the basic units of sticky peptide, leading to bacterial cell wall synthesis barriers, resulting in bacterial cell wall defects and play a bactericidal effect.