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目的观察归肾丸合克罗米芬(CC)治疗排卵障碍性不孕症的临床效果。方法选择排卵障碍性不孕症68例,随机分为2组:观察组35例,于月经周期第5天起服用CC50mg/d,共5d,并服用归肾丸,每日1剂,共10d;对照组33例,服用CC方法同观察组。2组于月经周期第9天开始行阴道B超检查,记录卵泡数目和大小,测量子宫内膜厚度。卵泡接近成熟时每日做妇科检查,进行宫颈黏液评分。卵泡成熟后触发排卵,于排卵后第7天测血雌二醇(E2)、孕酮(P),排卵后14d检测血或尿HCG,以确定是否妊娠。结果观察组HCG日宫颈黏液评分、子宫内膜厚度明显优于对照组(P<0.05);2组卵泡直径比较无显著性差异(P>0.05)。黄体高峰期观察组血清E2、P水平均高于对照组(P<0.05)。观察组治愈率、总有效率及妊娠率均明显高于对照组(P<0.05)。结论归肾丸合克罗米芬治疗排卵障碍性不孕症可增加子宫内膜厚度,改善宫颈黏液评分、黄体功能,能有效提高排卵率及妊娠率。
Objective To observe the clinical effect of Guishen Pills combined with clomiphene citrate (CC) in the treatment of ovulatory dysplasia. Methods Sixty-eight cases of infertility with ovulation disorder were randomly divided into two groups: 35 cases in observation group and CC50 mg / d on day 5 of menstrual cycle, taking Guishen Pills for 1 day for 10 days ; Control group of 33 cases, taking the CC method with the observation group. Group 2 in the menstrual cycle began on the 9th day vaginal ultrasound B, recording the number and size of follicles, measuring the thickness of the endometrium. Follicles close to maturity daily gynecological examination, cervical mucus score. Ovulation was triggered after the follicles matured. Blood estradiol (E2) and progesterone (P) were measured on the 7th day after ovulation, and blood or urine HCG was detected on the 14th day after ovulation to determine whether they were pregnant. Results The HCG cervical mucus score and endometrial thickness in the observation group were significantly better than those in the control group (P <0.05). There was no significant difference in the diameters of follicles between the two groups (P> 0.05). The serum levels of E2 and P in the luteal phase observation group were higher than those in the control group (P <0.05). The cure rate, total effective rate and pregnancy rate in the observation group were significantly higher than those in the control group (P <0.05). Conclusion Guishen pill combined with clomiphene treatment of ovulation disorders infertility can increase the thickness of the endometrium, improve cervical mucus score, luteal function, can effectively improve the ovulation rate and pregnancy rate.