一、背景 实践证明，拉米夫定的问世推动了慢性乙型肝炎治疗的进程。《２０００年拉米夫定临床应用指导意见》［１］对帮助临床医生正确应用拉米夫定起了重要作用。随着时间的增加、临床应用病例数的增多，积累的经验也越来越丰富。在综合国内外文献基础上，结合我国的临床实践 First, the background Practice has proved that the advent of lamivudine to promote the treatment of chronic hepatitis B process. The “Lamivudine 2000 Clinical Guidance” [1] plays an important role in helping clinicians to properly use lamivudine. With the increase of time, the number of cases of clinical application has increased, and the accumulated experience has become more and more abundant. On the basis of a comprehensive domestic and foreign literature, combined with our clinical practice