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自1952年异烟肼问世以来,因过量服用异烟肼中毒引起周身惊厥已有报导。异烟肼是儿童常用的抗结核药物,这种药物中毒导致的惊厥是危险的,可危及生命,必须积极处理。本文报告4例急性异烟肼中毒。病例1:1(1/2)岁男孩,送到医院时周身惊厥,患儿1小时前无任何异常。体检除周身惊厥外无其它异常发现,当即静脉注射葡萄糖、安定(总量10mg)及苯妥英钠(150mg),均无效,最后用副醛6ml灌肠,惊厥始停
Since the advent of isoniazid in 1952, it has been reported that whole-body convulsions are caused by overdose of isoniazid. Isoniazid is commonly used in children’s anti-TB drugs, convulsions caused by this drug poisoning is dangerous and can be life-threatening, we must actively deal with. This article reports 4 cases of acute isoniazid poisoning. Case 1: 1 (1/2) year old boy, sent to the hospital when the whole body convulsions, 1 hour before the children without any exception. Physical examination except for convulsions outside the body found no other abnormalities immediately after intravenous glucose, diazepam (total 10mg) and phenytoin sodium (150mg) were ineffective, and finally with paracetamol 6ml enema, convulsions stopped