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目的比较依那普利、缓释硝苯地平对轻、中度高血压病患者的降压效果及耐受性。方法采用随机、双盲、平行对照法,将163例轻、中度高血压病患者分为依那普利组(82例,10mg/d)和缓释硝苯地平组(81例,20mg/d),治疗4周。以诊室血压为指标,比较2种药物的降压疗效,并观察2种药物对血糖、血脂、肝肾功能等的影响及不良反应。结果依那普利、缓释硝苯地平治疗轻、中度高血压病的总有效率分别为:81.71%、81.48(P>0.05)。2种药物不良反应发生率分别为8.54%、19.75%(P<0.01)。结论2种药物均有较好的降压效果,组间比较差异无显著性。不良反应依那普利较缓释硝苯地平少,均无严重不良反应,患者的耐受性好。
Objective To compare the antihypertensive efficacy and tolerability of enalapril with sustained release nifedipine in patients with mild and moderate essential hypertension. Methods 163 patients with mild to moderate hypertension were randomly divided into enalapril group (82 cases, 10 mg / d) and controlled release nifedipine group (81 cases, 20 mg / d) for 4 weeks. The clinic blood pressure was used as an index to compare the antihypertensive efficacy of the two drugs. The effects of the two drugs on blood glucose, blood lipid, liver and kidney function, and adverse reactions were observed. Results The total effective rate of enalapril and sustained-release nifedipine in treating mild and moderate hypertension were 81.71% and 81.48, respectively (P> 0.05). Adverse reactions of the two drugs were 8.54% and 19.75% respectively (P <0.01). Conclusion Both drugs have better antihypertensive effect, no significant difference between groups. Adverse reactions enalapril no more than the sustained release of nifedipine, no serious adverse reactions, patients with good tolerance.