为进一步探讨肿瘤坏死因子（ｔｕｍｏｒｎｅｃｒｏｓｉｓｆａｃｔｏｒ，ＴＮＦ）和白细胞介素６（ｉｎｔｅｒｌｅｕｋｉｎ６，ＩＬ６）在ＧＢＳ免疫病理机制中的作用，采用放射免疫法ＥＩＬＳＡ法对３７例ＧＢＳ患者、３５例其它神经系统疾病患者及３０例正常人血清中的ＴＮＦ和ＩＬ６水平进行了测定。结果ＧＢＳ患者血清ＴＮＦ水平增高，与其它神经系统疾病组比较差异显著（Ｐ＜０．０１）；ＧＢＳ患者血清ＩＬ６检测阳性率为６２．１６％，与其它神经系统疾病组及正常对照组比较差异显著（Ｐ＜０．００１）。进一步分析发现ＧＢＳ患者血清ＴＮＦ和ＩＬ６升高的水平与病情轻重有关。我们的结果提示ＧＢＳ患者免疫功能失调，ＴＮＦ和ＩＬ６可能参与了ＧＢＳ的免疫病理机制，且与病情轻重有关 To further investigate the role of tumor necrosis factor (TNF) and interleukin 6 (IL-6) in GBS immunopathological mechanism, 37 patients with GBS and 35 patients with other neurological diseases were treated with radioimmunoassay Patients and 30 normal serum TNF and IL  6 levels were measured. Results The level of serum TNF in GBS patients was significantly higher than that in other neurological diseases (P <0.01). The positive rate of serum IL6 in GBS patients was 62.16%. Compared with other neurological diseases and normal controls The difference was significant (P <0.001). Further analysis found that GBS patients with elevated serum TNF and IL  6 levels and severity of the disease. Our results suggest that GBS patients with immune dysfunction, TNF and IL 6 may be involved in the immune pathology of GBS, and the severity of the disease