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目的采用替米沙坦对胰岛素抵抗大鼠进行干预,观察其对胰岛素抵抗大鼠心肌早期炎症因子IL-6及血脂的影响。方法建立大鼠胰岛素抵抗模型,应用替米沙坦进行干预。生化检测血清胰岛素及血脂水平,免疫组化法检测心肌IL-6水平,所有资料以SPSS13.0统计软件进行分析,连续性计量资料,数据以士s表示,两组间的比较采用t检验。结果葡萄糖输注率:干预组明显高于非干预组而仍明显低于对照组(P<0.05);血脂:非干预组TC、TG、LDL-C更加明显高于对照组,高于干预组,HDL-C则相反(P=0.00 0.05);炎症因子IL-6的表达:试验中在空白对照组心肌中未见表达,干预组与未干预组间相比有显著性差异(P<0.05)而与空白对照组间无统计学差异。结论胰岛素抵抗状态下大鼠心肌IL-6表达增强;ARB除了具有控制血糖及降低血脂的作用,同时能改善胰岛素抵抗状态;ARB可以改善胰岛素抵抗状态的慢性炎症反应。
OBJECTIVE: To investigate the effect of telmisartan on insulin resistance in rats and its effect on early inflammatory cytokine IL-6 and lipids in myocardium of insulin resistance rats. Methods Rat insulin resistance model was established and treated with telmisartan. Biochemical tests were performed to detect serum insulin and lipid levels. The level of IL-6 in myocardium was detected by immunohistochemistry. All data were analyzed by SPSS13.0 statistical software. The data of continuous measurement were expressed as s ± s. The t-test was used to compare the two groups. Results The glucose infusion rate was significantly higher in intervention group than in non-intervention group and still lower than that in control group (P <0.05). TC, TG and LDL-C in serum and non-intervention group were significantly higher than those in control group , While HDL-C was the opposite (P = 0.00 0.05). The expression of IL-6 was not found in the myocardium of the blank control group, and there was a significant difference between the intervention group and the non-intervention group ) And no significant difference between the control group. Conclusion ARB can increase the level of IL-6 in myocardium of rats with insulin resistance. ARB can not only improve blood glucose and blood lipid but also improve insulin resistance. ARB can improve the chronic inflammatory response of insulin resistance.