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一氧化氮（ＮＯ）是内皮衍化舒张因子（ＥＤＲＦ）的主要作用成分，它除了具有舒血管作用外，还具有舒气管作用。而支气管哮喘是以支气管平滑肌收缩及气道高反应性为主要表现的疾病，因此，为了研究ＮＯ在支气管哮喘发病中的作用，我们采用雾化吸入卵蛋白复制豚鼠哮喘模型，发现哮喘组发作期支气管肺泡灌洗液（ＢＡＬＦ）中ＮＯ水平较对照组高，Ｐ＜０．０１，且气道损伤明显。在用易顺脉治疗后，ＢＡＬＦ中ＮＯ水平也是升高的，但较单纯哮喘组无明显差异，Ｐ＞０．０５，气道损伤改善。这些结果提示了ＮＯ可能在支气管哮喘的发生和发展过程中起一定的作用。
Nitric oxide (NO) is the main component of endothelium-derived relaxing factor (EDRF), which not only has vasodilator effect, but also has the effect of tracheal tube. Bronchial asthma is a bronchial smooth muscle contraction and airway hyperresponsiveness as the main manifestation of the disease, therefore, in order to study the role of NO in the pathogenesis of bronchial asthma, we use atomized inhaled egg protein replication guinea pig asthma model and found that asthma group attack Bronchoalveolar lavage fluid (BALF) NO levels higher than the control group, P <0.01, and airway damage significantly. After treated with Yihun pulse, the level of NO in BALF was also increased, but there was no significant difference between the two groups (P> 0.05). The airway injury was improved. These results suggest that NO may play a role in the development and progression of bronchial asthma.