异环磷酰胺引起脑病的作用机制尚未明了。一名患转移性骨癌的病人在过量应用异环磷酸胺（24h静注25g）后，尿中大量排出戊二酸和肌氨酸（符合戊二酸尿Ⅱ型），这表明有可能对异环磷酰胺脑病作出解释：戊二酸尿Ⅰ型是由于缺乏戊二醋－CoA（辅酶川脱氢酶，戊二酸尿Ⅱ型是由于缺乏 Ifosfamide causes encephalopathy mechanism of action is not yet clear. In a patient with metastatic bone cancer, glutamate and sarcosine (consistent with glutaric acid excretion type II) were excreted largely in urine after an overdose of isocyclosporine (24 h intravenous injection of 25 g), suggesting that it is possible Ifosfamide encephalopathy to explain: glutaric acid urine type Ⅰ is due to the lack of glutathione - CoA (coenzyme DHEA, glutaric acid urine type Ⅱ is due to lack of