目的探讨伽玛刀治疗泌乳素型垂体腺瘤的疗效。方法回顾性分析260例伽玛刀治疗的泌乳素型垂体腺瘤患者,以50%等剂量曲线包绕靶区,中心剂量30～60Gy,并确保视神经视交叉接受剂量<9Gy。随访观察治疗效果。结果随访时间6～48个月,肿瘤缩小216例(83.08%),无变化25例(9.62%),增大19例(7.31%),肿瘤控制率92.70%。结论伽玛刀治疗泌乳素型垂体腺瘤有效率高,安全性好。 Objective To investigate the therapeutic effect of gamma knife on prolactin-type pituitary adenoma. Methods A retrospective analysis of 260 patients with prolactin-type pituitary adenomas treated with gamma knife was performed. The target dose was 30-60 Gy in a 50% isodose curve and the dose of optic chiasm was <9 Gy. Follow-up observation of the therapeutic effect. Results The follow-up time ranged from 6 months to 48 months. Tumors were reduced in 216 cases (83.08%), unchanged in 25 cases (9.62%), increased in 19 cases (7.31%), and tumor control rate was 92.70%. Conclusion Gamma knife treatment of prolactin pituitary adenoma with high efficiency and good security.