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目的:分析474例唾液腺腺样囊性癌(adenoid cystic carcinoma,ACC)的临床病理特征。方法:回顾分析上海交通大学医学院附属第九人民医院口腔病理科诊断为原发性ACC的474例临床病理资料。采用SPSS18.0软件包对数据进行统计学处理。结果:474例ACC中,男女之比为1.03∶1(240∶234);发病年龄11~83岁,平均年龄52岁;腮腺和腭部分别是大小唾液腺中最常见的部位;病程1个月~37 a不等,平均21个月;64%的患者出现不同程度的症状;72%的患者就诊时TNM分期为Ⅱ期和Ⅲ期;组织学上,76%的患者表现为筛状/管状型。组织学类型为实体型者较筛状/管状型者更易发生颈淋巴结转移(P=0.016)。结论:ACC多见于中老年人,腮腺和腭部最常见。临床上多伴有不同程度的症状,组织学表现以筛状/管状型多见,实体型者更易发生颈淋巴结转移。
Objective: To analyze the clinicopathological features of 474 cases of adenoid cystic carcinoma (ACC). Methods: A retrospective analysis of 474 cases diagnosed as primary ACC in the Department of Stomatology of the Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine was performed. SPSS18.0 software package for statistical analysis of the data. Results: In 474 cases of ACC, the ratio of male to female was 1.03:1 (240: 234). The age of onset was from 11 to 83 years with a mean age of 52 years. Parotid and palate were the most common sites in salivary glands ~ 37 a, with an average of 21 months; 64% of patients showed varying degrees of symptoms; 72% of TNM stages were stage II and III; histologically, 76% type. Cervical lymph node metastasis was more likely to occur in the histologic type as compared with the lamina / tubular type (P = 0.016). Conclusion: ACC is more common in the elderly, parotid and palate most common. Clinically accompanied by varying degrees of symptoms, histological manifestations of mesh / tubular more common, solid type are more likely to cervical lymph node metastasis.