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目的评价秋水仙碱治疗复发性阿弗他溃疡(RAU)的疗效。方法选择2008年5月至2010年1月来江苏省苏北人民医院口腔科就诊的RAU患者112例,随机分成两组。对照组(56例)应用锡类散喷于溃疡表面,3～4次/d,至溃疡愈合;试验组(56例)在同对照组用药基础上给予秋水仙碱(5mg/次)口服,疗程为12周,第1周1次/d,第2周2次/d,第3～12周3次/d。结果治疗后1年,试验组总有效率为97.87%,对照组总有效率为46.67%,两组疗效比较,差异有统计学意义(P<0.01)。结论秋水仙碱治疗RAU有较好的疗效。
Objective To evaluate the efficacy of colchicine in the treatment of recurrent aphthous ulcer (RAU). Methods From May 2008 to January 2010, 112 patients with RAU who visited Jiangsu Provincial Department of Stomatology, People’s Hospital of Jiangsu Province were randomly divided into two groups. In the control group (56 cases), tin powder was sprayed on the ulcer surface 3 to 4 times / d to heal the ulcer; the experimental group (56 cases) was given colchicine (5mg / time) on the basis of the control group, Treatment for 12 weeks, 1 week 1 / d, 2 weeks 2 times / d, 3 to 12 weeks 3 times / d. Results One year after treatment, the total effective rate was 97.87% in the experimental group and 46.67% in the control group. The difference between the two groups was statistically significant (P <0.01). Conclusion colchicine treatment of RAU has a good effect.