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目的观察维生素B12对肝硬化失代偿期伴中度贫血患者红细胞(RBC)、血红蛋白(Hb)、网织红细胞计数的影响。方法将肝硬化失代偿期伴中度贫血患者60例随机分成对照组30例,治疗组30例,分别给予基础保肝及联合维生素B12综合治疗,观测两组RBC、Hb及网织红细胞数值,分析维生素B12的治疗作用。结果治疗组治疗后RBC、Hb、网织红细胞与治疗前比较差异有统计学意义(P<0.01);治疗组与对照组治疗后比较RBC、Hb、网织红细胞计数差异有统计学意义(PRBC<0.05,PHb<0.01,P网织红细胞<0.01)。结论维生素B12可有效改善肝硬化失代偿期贫血症状。
Objective To observe the effect of vitamin B12 on erythrocyte (RBC), hemoglobin (Hb) and reticulocyte count in patients with decompensated cirrhosis and moderate anemia. Methods Sixty patients with decompensated cirrhosis and moderate anemia were randomly divided into control group (n = 30) and treatment group (n = 30). The patients were given basic hepatoprotective and combined vitamin B12 treatment respectively. The RBC, Hb and reticulocyte count , Analysis of the therapeutic effect of vitamin B12. Results After treatment, the RBC, Hb and reticulocytes in treatment group were significantly different from those before treatment (P <0.01), and the difference of RBC, Hb and reticulocyte count between treatment group and control group after treatment was statistically significant (PRBC <0.05, PHb <0.01, P reticulocyte <0.01). Conclusion Vitamin B12 can effectively improve the symptoms of decompensated cirrhosis and anemia.