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应用溶剂-熔融法将葛根大豆甙元与载体poloxamer制成不同比例的共沉淀物以提高药物的溶出速度。采用差热分析和热台显微镜技术,测得其组成中含药物2.1%时共熔点为44℃,偏光显微镜观察及X射线图谱表明,1.7%以下的共沉淀物为固溶体,2.1%的共沉淀物中,甙元以最微细的晶体分散于载体中,在人工肠液中溶出速度和平衡溶解度测定显示,溶出度(T_(60))1%为2min,2.1%为4min,甙元约为60min,相应的平衡溶解度分别为52.47、35.30和4.37μg/ml(37±0.5℃)。
Application of solvent - melting method Puerarin daidzein and carrier poloxamer made of different proportions of coprecipitate to improve drug dissolution rate. Using differential thermal analysis and hot stage microscopy, the melting point at 2.1% of the drug-containing composition was determined to be 44 ° C. Polarizing microscopy and X-ray spectroscopy showed that 1.7% or less of the coprecipitates were solid solutions and 2.1% coprecipitates The results showed that the dissolution rate (T_ (60)) was 1% for 2min, 2.1% for 4min, aglycone was about 60min The corresponding equilibrium solubilities were 52.47, 35.30 and 4.37 μg / ml, respectively (37 ± 0.5 ° C).