论文部分内容阅读
目的 :分析恶性血液病患者血清免疫抑制酸性蛋白 (IAP)的变化及临床意义。方法 :应用单向免疫琼脂扩散法检测 5 0例恶性血液病和 15例非恶性血液病患者血清IAP水平。结果 :恶性血液病患者血清IAP水平明显增高 ,与健康对照组相比有显著差异 (P <0 0 1)。非恶性血液病患者与健康对照组无统计学差异。动态观察急慢性白血病不同病期IAP变化表明 :初治与未缓解病人IAP增高明显 ,缓解期水平下降 ,IAP持续增高病人往往预后不良。结论 :提示IAP做为一种肿瘤相关标志 ,对血液系统恶性肿瘤的临床诊断、疗效观察、预后判断及监测复发是一个有用的指标
Objective: To analyze the changes of serum immunosuppressive acid protein (IAP) in patients with hematologic malignancies and its clinical significance. Methods: The level of serum IAP in 50 patients with hematologic malignancies and 15 patients with non-hematologic malignancies was detected by one-way immunogold agar diffusion assay. Results: The level of serum IAP in patients with hematologic malignancies was significantly higher than that in healthy controls (P <0.01). There was no significant difference between non-hematologic malignancies and healthy controls. Dynamic observation of acute and chronic leukemia at different stages of IAP changes showed that: patients with initial and non-alleviated IAP increased significantly decreased levels of remission, IAP continued to increase patients often have poor prognosis. Conclusion: It is suggested that IAP as a tumor-related marker is a useful indicator of the clinical diagnosis, curative effect, prognosis and recurrence of hematological malignancies