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选择环境氟水平相同硒水平不同的地方性氟中毒区进行环境氟、硒含量、人群氟、硒中毒以及血清中超氧歧化酶（ＳＯＤ）、丙二醛（ＭＤＡ）水平等项调查。结果表明高硒临界水平调查点居民氟中毒、硒中毒检出率明显高于正常硒水平调查点的居民（Ｐ＜０．０５），且居民尿氟、血硒明显增加（Ｐ＜０．００１），血清中ＳＯＤ值明显下降（Ｐ＜０．００１），ＭＤＡ值明显增高（Ｐ＜０．０５）。提示高硒高氟可使机体内超氧歧化酶活性下降，脂质过氧化作用增强，从而加重了氟、硒中毒程度，即高氟高硒共存环境硒氟对机体影响表现为协同作用
The levels of fluorine and selenium, fluorine and selenium in the population and levels of serum superoxide dismutase (SOD) and malondialdehyde (MDA) in the endemic fluorosis area with the same level of fluoride were compared. The results showed that the detection limit of selenium poisoning was significantly higher than that of residents at the survey point of normal selenium (P <0.05), and urinary fluoride and blood selenium were significantly increased (P <0.001 ), Serum SOD decreased significantly (P <0.001), MDA increased significantly (P <0.05). These results suggest that high selenium and high fluoride can decrease the activity of superoxide dismutase and increase the lipid peroxidation in the body, which aggravates the poisoning of fluoride and selenium, that is, the effect of high fluorine and high selenium on the body is synergistic