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将６２例绝经期病人按１：１随机分为２组，实验组口服国产短效戊酸雌二醇１ｍｇ·ｄ－１，对照组口服结合雌激素０．６２５ｍｇ·ｄ－１，并与醋酸甲孕酮４ｍｇ连续序贯应用治疗１６周，分别于用药前、用药后９周、用药后１６周测定空腹血糖、血胰岛素及血雌二醇水平，测口服糖耐量２ｈ血糖和血胰岛素水平，并计算空腹血糖和血胰岛素乘积的倒数作为胰岛素敏感指数；分析年龄与用药前空腹血糖、空腹胰岛素、胰岛素敏感性的相关关系。结果表明，两组用药后空腹血糖和空腹胰岛素水平显著性下降，胰岛素敏感性显著改善，血雌二醇水平明显上升。用药１６周后对照组空腹血糖和空腹胰岛素水平明显低于实验组，但胰岛素敏感性无显著性差异。年龄与用药前空腹血糖水平正相关，与胰岛素敏感性负相关。说明了激素替代治疗有益于糖代谢。
Sixty-two menopausal patients were randomly divided into two groups according to the ratio of 1: 1. The experimental group was orally given domestic short-acting estradiol valerate 1 mg · d-1, the control group orally combined with estrogen 0.625 mg · d-1, Median progesterone 4mg for sequential treatment of 16 weeks of treatment, respectively, before treatment, 9 weeks after treatment, 16 weeks after treatment determination of fasting blood glucose, blood insulin and serum estradiol levels measured oral glucose tolerance 2h blood glucose and insulin levels, And calculate the reciprocal of the product of fasting blood glucose and insulin as insulin sensitivity index; Analysis of age and medication before fasting blood glucose, fasting insulin, insulin sensitivity of the relationship. The results showed that both fasting blood glucose and fasting insulin levels decreased significantly after treatment, insulin sensitivity significantly improved, blood estradiol levels increased significantly. After 16 weeks of treatment, fasting blood glucose and fasting insulin levels in the control group were significantly lower than those in the experimental group, but there was no significant difference in insulin sensitivity. Age and fasting blood glucose levels before the drug is positively correlated, and negatively correlated with insulin sensitivity. Shows that hormone replacement therapy is beneficial to glucose metabolism.