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6氨基2-n戊硫苯噻唑(APB)是一种苯噻唑类新抗真菌剂,体外能抑制念珠菌属的酵母样真菌的菌丝和孢子间的转换及芽管产生;体内治疗实验性念珠菌病有效。其效用与唑类药物相似。但作用机理不同。唑类是在C-14脱甲基步骤抑制念珠菌胞壁的麦角甾醇的生物合成,而APB是在C-4去甲基步骤抑制甾醇生物合成,APB在体内对皮肤癣病的研究尚未报告。该文研究APB对3种毛癣菌在体内、外的抗菌活性。
6 Amino 2-n Pentafluridine (APB) is a new benzothiazole antifungal agent that inhibits the transformation of mycelium and spores of Candida-like yeast-like fungi and the germination of germ tubes in vitro. Experimental in vivo treatment Candidiasis effective. Its effectiveness and azole drugs similar. But the mechanism of action is different. Azoles inhibit the biosynthesis of ergosterol in the cell wall of Candida in the C-14 demethylation step whereas APB inhibits sterol biosynthesis in the C-4 demethylation step and the study of APB in vivo on dermatophytosis has not been reported . This article studies the antimicrobial activity of APB against Trichophyton rubrum in vitro and in vivo.